CONTROLLED DELIVERY OF HIV DRUG BY USING MUCOADHESIVE POLYMER
نویسندگان
چکیده
منابع مشابه
Preactivated thiolated glycogen as mucoadhesive polymer for drug delivery.
The purpose of this study was to synthesize and characterize a novel thiolated glycogen, so-named S-preactivated thiolated glycogen, as a mucosal drug delivery systems and the assessment of its mucoadhesive properties. In this regard, glycogen-cysteine and glycogen-cysteine-2-mercaptonicotinic acid conjugates were synthesized. Glycogen was activated by an oxidative ring opening with sodium peri...
متن کاملMucoadhesive Polymer Hyaluronan as Biodegradable Cationic/Zwitterionic-Drug Delivery Vehicle
Mucoadhesive polymers in pharmaceutical formulations release drugs in mucosal areas. They interact and fix to mucus through molecular interpenetration, etc., which increase drug bioavailability. Polymers physicochemical properties affect formulation mucoadhesion, rheological behaviour and drug absorption. Hyaluronan (HA) is selected as a mucoadhesive and biodegradable polymer. Geometric, topolo...
متن کاملMucoadhesive drug delivery systems
Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diff...
متن کاملMucoadhesive Microspheres as a Controlled Drug Delivery System for Gastroretention
Context: Drugs that are easily absorbed from the gastrointestinal tract (GIT) and have a short halflife are eliminated quickly from the blood circulation, require frequent dosing. To avoid this, the oral controlled release (CR) formulations have been developed in an attempt to release the drug slowly into the GIT and maintain a constant drug concentration in the serum for longer period of time....
متن کاملMucoadhesive Microparticles Engineered for Ophthalmic Drug Delivery.
Although topical drug delivery is a convenient route of administration to treat various eye diseases, it has serious limitations due to rapid clearance of the formulation from the surface of the eye. In this study, we engineered microparticles for both sustained drug delivery and prolonged residence time on the extraocular surface. Microparticles were fabricated by emulsification using poly(lac...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Pharmaceutical and Scientific Innovation
سال: 2019
ISSN: 2277-4572
DOI: 10.7897/2277-4572.084144